Entry name i: TNR9_HUMAN: Accession i: Q07011 Primary (citable) accession number: Q07011: Entry history i: Integrated into UniProtKB/Swiss-Prot: : February 1, 1995: Last sequence update: : February 1, 1995: Last modified: : April 7, 2021: This is version 184 of the entry and version 1 of the sequence. See complete history.: Entry status i: Reviewed (UniProtKB/Swiss-Prot): Annotation program

EphA2/CD137 TICAs which engage EphA2 and CD137 simultaneously with high affinity resulting in picomolar potency. EphA2/CD137 TICAs potentiate tumor target dependent cytokine secretion in immune co-culture experiments and promote caspase activity in T cell mediated cell killing assays.

It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. 2020-11-21 · CD137-directed natural killer (NK)/NKT cells play an important role in the inflammatory response leading to the production of proinflammatory cytokines, lipopolysaccharide-induced septic shock, and tumor killing, as well as IL-4-dependent Th2 responses. CD137 engagement reduces follicular dendritic cell networks in a T cell-dependent manner. CD137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation.

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Hence, akin to other members of the TNFR family, it relies on the TNFR-Associated-Factor (TRAF) family of adaptor proteins to build the CD137 signalosome for transducing signals into the cell. Know comprehensive CD137 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction. CD137 is expressed in activated human B cells, 13 T FH, 10 and follicular dendritic cells. 14 CD137 has been shown to be essential for B-cell function, including activation, affinity maturation, proliferation, and class switch recombination (CSR) through its interaction with CD137L in germinal centers. 14-16 We thus hypothesized that these functions may be impaired in patient B cells. CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells.

CD137-transfected L-428 cells (L-428-CD137) were treated with 10 μg/ml of Fabs, followed by anti-Fab-AF647. All Fabs bound efficiently to CD137 + cells ( Supplementary Figure 3 ). No binding was observed to CD137 − L-428-control cells (not shown).

antitumöreffekt och förstärker effekten av behandling med anti-PD-1 och anti-CD137 i djurmodeller --. Immunicum AB (publ; IMMU.

CD137, also known as 4-1BB, is a member of the TNFR super family. CD137 is closely related to CD27, OX40, and CD30. It is up-regulated on mouse and human T cells upon activation.

4-1BB (CD137) is a costimulatory member of the tumor necrosis factor receptor superfamily that is upregulated on activated T cells, NK cells, NKT cells, and monocytes. 4-1BB is …

These findings   Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor  CD137, also known as 4-1BB, is a TNFR family member that is expressed on activated T cells, NK cells and a number of other activated cells of hematopoietic   Human CD137 (4-1BB), FC Fusion (ILA ); Human secreted CD137, Fc fusion protein, also known as Tumor Necrosis Factor Receptor Superfamily member 9,  24 Mar 2020 CD137 (also known as 4-1BB and TNFRSF9) and its ligand,. CD137L (also called 4-1BBL or TNFSF9), are expressed on a variety of  Although CD137 has been cloned from activated T cells in mouse and man [3, 4], its expression has been detected subse- quently on NK cells, monocytes, DCs, B   15 Apr 2020 CD137 is expressed on a subset of FOXP3+ regulatory CD4 T cells (Tregs), and CD137+ Tregs are the main source of soluble CD137. Soluble  CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses (1). The functions  T1 - Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells. AU - Lindstedt, Malin.

Soluble  CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses (1). The functions  T1 - Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells.
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The potency of CD137 co-stimulation in enabling the immune system to elimi-nate tumors has been documented in a wide plethora of murine tumor models including mastocytoma, sarcoma, colon carci- CD137 is a potent costimulatory receptor. Several agonistic anti‐CD137 antibodies are currently in clinical trials for tumor immunotherapy.

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CD137. CD137 expressed on blood vessels in inflamed tissue correlates with markers of vascular inflammation, and the use of an anti-CD137 antibody promotes the accumulation of T cells in atherosclerotic lesions in a murine model [63]. From: Journal of Autoimmunity, 2020. Related terms: Neoplasm; T Cell; Antigen; Antibody; Immunotherapy; Ligand

REVIEW CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses Bhushan Dharmadhikari a, Meihui Wu , Nur Sharalyn Abdullah a, Sakthi Rajendran , Nur Diana Ishak , Emily Nickles , Zulkarnain Harfuddin a, b, and Herbert Schwarz, aDepartment of Physiology, and Immunology Programme, National University of Singapore, Singapore; bNUS Graduate School for Integrative Sciences CD137 agonistic activity, their clinical use is limited to can-cer patients who highly express the antigen. This is in sharp contrast to anti–PD-1/PD-L1 antibody and anti-CTLA4 antibody, which can be used for patients without consid-ering the expression of specific tumor-associated antigen. Anti-CD137 mAb is currently undergoing phase I and II clinical trials for cancer [28]. In preclinical models, immunotherapeutic doses of CD137-speciWc mAb have not shown serious deleterious eVects. Described toxic eVects include myelosuppression [33] mediated by cytokines released in the bone marrow microenvironment. CD137 is a costimulatory member of the TNF receptor superfamily that is expressed on a variety of immune cells following activation, including T cells, dendritic cells, and natural killer cells. Signaling via CD137 can lead to cytokine induction, prevention of activation-induced cell death, and CD137 ligand signaling induces human monocyte to dendritic cell differentiation Shaqireen Kwajah M. M. and Herbert Schwarz Department of Physiology and Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore The ligand for CD137 (4-1BB) is expressed on peripheral human monocytes and delivers a CD137 tumor necrosis factor receptor superfamily member 9, Doxy doxycycline, MAPK mitogen-activated protein kinase, siCTL control siRNA, siMAPK1 siRNA against MAPK1, PCR polymerase chain reaction.